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How An Initial Injury Leads to Reinjury

1. Persistent Biomechanical Deficits

After an initial injury, abnormal movement patterns, altered gait, joint instability, and reduced range of motion can increase mechanical stress on the injured site and surrounding tissues. These deficits may lead to compensatory movements, elevating the risk of reinjury [Hewett et al., 2013; Kim et al., 2019].

 

2. Maladaptive Neuromuscular Changes

Injury can cause long-lasting alterations in both the central and peripheral nervous systems, leading to neuromuscular inhibition and maladaptive neuroplasticity [Coderre et al., 1993].

Neuromuscular inhibition: Persistent inhibition of motor units contributes to muscle weakness and is commonly observed in ACL and hamstring injuries [Hewett et al., 2013; Fyfe et al., 2013].

Maladaptive neuroplasticity: Altered proprioception, delayed reflexes, and peripheral sensory deficits (e.g., joint instability) disrupt normal communication between the joint and the CNS [Shitara et al., 2022; Neto et al., 2019].

Persistence after healing: These changes can remain even after tissue repair, reducing strength, coordination, and protective reflexes. Standard functional tests may not detect these deficits, which can result in premature return to activity and increased reinjury risk [Needle et al., 2024; Grooms et al., 2023].

3. Inadequate Rehabilitation

Incomplete, overly aggressive, or delayed rehabilitation can result in scar tissue formation, fibrosis, chronic inflammation, and incomplete tissue remodeling. These changes compromise joint stability, proprioception, muscle strength, and range of motion, leaving tissues vulnerable to reinjury [Tran et al., 2023; Rockey et al., 2015; Kohlhauser et al., 2024; Moretti et al., 2022; Kaneguchi et al., 2022; Sharma & Pai, 1997; Proske & Gandevia, 2012].

References:

Coderre, T.J., Katz, J., Vaccarino, A.L. and Melzack, R. (1993) ‘Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence’, Pain, 52(3), pp. 259–285. https://doi.org/10.1016/0304-3959(93)90161-H

Fyfe, J.J., Opar, D.A., Williams, M.D. and Shield, A.J. (2013) ‘The role of neuromuscular inhibition in hamstring strain injury recurrence’, Journal of Electromyography and Kinesiology, 23(3), pp. 523-530. https://doi.org/10.1016/j.jelekin.2012.12.006

Grooms, D.R., Chaput, M., Simon, J.E. et al. (2023) ‘Combining neurocognitive and functional tests to improve return-to-sport decisions following ACL reconstruction’, Journal of Orthopaedic & Sports Physical Therapy, 53(8), pp. 415–419. https://doi.org/10.2519/jospt.2023.11489

Hewett, T.E., Di Stasi, S.L. and Myer, G.D. (2013) ‘Current concepts for injury prevention in athletes after anterior cruciate ligament reconstruction’, American Journal of Sports Medicine, 41(1), pp. 216–224. https://doi.org/10.1177/0363546512459638

Kaneguchi, A. and Ozawa, J. (2022) ‘Inflammation and fibrosis induced by joint remobilization, and relevance to progression of arthrogenic joint contracture: a narrative review’, Physiological Research, 71, pp. S137–S147. https://pubmed.ncbi.nlm.nih.gov/35770468/

Kim, H., Son, S.J., Seeley, M.K. and Hopkins, J.T. (2019) ‘Altered movement strategies during jump landing/cutting in patients with chronic ankle instability’, Scandinavian Journal of Medicine & Science in Sports, 29(8), pp. 1130–1140. https://doi.org/10.1111/sms.13445

Kohlhauser, M., Mayrhofer, M., Kamolz, L.P. and Smolle, C. (2024) ‘An update on molecular mechanisms of scarring: a narrative review’, International Journal of Molecular Sciences, 25. https://pubmed.ncbi.nlm.nih.gov/39519131/

Moretti, L., Stalfort, J., Barker, T.H. and Abebayehu, D. (2022) ‘The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation’, Journal of Biological Chemistry, 298. https://pubmed.ncbi.nlm.nih.gov/34953859/

Needle, A.R., Howard, J.S., Downing, M.B. and Skinner, J.W. (2024) ‘Neural-targeted rehabilitation strategies to address neuroplasticity after joint injury’, Journal of Athletic Training, 59(12), pp. 1187–1196. https://doi.org/10.4085/1062-6050-0215.23

Neto, T., Sayer, T., Theisen, D. and Mierau, A. (2019) ‘Functional brain plasticity associated with ACL injury: a scoping review’, Neural Plasticity, 2019, Article ID 3480512. https://doi.org/10.1155/2019/3480512

Proske, U. and Gandevia, S.C. (2012) ‘The proprioceptive senses: their roles in signaling body shape, body position and movement, and muscle force’, Physiological Reviews, 92(4), pp. 1651–1697. https://pubmed.ncbi.nlm.nih.gov/23073629/

Rockey, D.C., Bell, P.D. and Hill, J.A. (2015) ‘Fibrosis — a common pathway to organ injury and failure’, New England Journal of Medicine, 372(12), pp. 1138–1149. https://pubmed.ncbi.nlm.nih.gov/25785971/

Sharma, L. and Pai, Y.C. (1997) ‘Impaired proprioception and osteoarthritis’, Current Opinion in Rheumatology, 9(3), pp. 253–258. https://pubmed.ncbi.nlm.nih.gov/9204262/

Shitara, H., Ichinose, T., Shimoyama, D. et al. (2022) ‘Neuroplasticity caused by peripheral proprioceptive deficits’, Medicine & Science in Sports & Exercise, 54(1), pp. 28–37. https://doi.org/10.1249/MSS.0000000000002775

Tran, N.T., Jeon, S.H., Moon, Y.J. and Lee, K.B. (2023) ‘Continuous detrimental activity of intra-articular fibrous scar tissue in correlation with posttraumatic ankle osteoarthritis’, Scientific Reports, 13. https://pubmed.ncbi.nlm.nih.gov/37973826/

 

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